NITRC–the Neuroimaging Informatics Tools and Resources Clearinghouse–recently passed the 3,000 registered users level and now has 383 registered tools available for users. TCG built and operates NITRC for NIH. Under this contract, TCG established a web-based clearinghouse for neuroimaging analysis tools, vocabularies, datasets, and databases to facilitate the dissemination of these resources and the discussion of needs and limitations. The site provides opportunities for community comment on neuroimaging informatics knowledge resources to guide development and enhance their use by the research community. The NITRC initiative also offers a framework for other scientific areas: tools and resources created under Federal grants for scientific research in any specialty can be shared with scientific communities using the NITRC approach. For more details on NITRC, see our case study on TCG’s web site.